ea0011oc9 | Steroids and reproductive endocrinology | ECE2006
Coutinho AE
, Gray M
, Sawatzky DA
, Brownstein D
, Mullins J
, Seckl JR
, Savill JS
, Chapman KE
Although the anti-inflammatory effects of exogenous glucocorticoids (GC) upon inflammation are well recognized, the contribution of 11β-hydroxysteroid dehydrogenase 1 (11β-HSD1), an amplifier of GC action in vivo, in modulating endogenous GC action during inflammation is unknown. Mouse models of arthritis and lung inflammation were used to explore the role of 11β-HSD1 in acute and chronic inflammation. Arthritis was induced in 11β-HSD1−/&#...